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USP美国药典 液相方法色谱柱汇总  

2010-10-27 10:19:36|  分类: 药物分析 |  标签: |举报 |字号 订阅

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液色迷人http://hplc2.blog.163.com

USP即美国药典,为高效液相色谱柱填料规定了一些指标,即USP L1---USP L60系列。

用户经常会在文献和技术开发中遇到用符合USP L系列方法的液相柱分离的要求,为此把符合此方法的液相柱作一列表,供您参考!

 

USP

填料描述

推荐色谱柱

L1

C18烷基化学键合于多孔硅胶或陶瓷微粒,3-10u

C18: COSMOSIL, Polaris,

L2

C18烷基化学键合于多孔硅胶,30-50u

C18分离填料:FUJI 填料 

L3

多孔硅胶微粒,5-10u

SIL: COSMOSIL, Polaris

L4

硅胶微粒,30-50u

 

L5

氧化铝微粒,30-50u

 

L6

强阳离子交换填料:磺化氟碳聚合物涂于固体球形核粒上,30-50u

 

L7

C8烷基化学键合于3-10u完全多孔硅胶微粒

C8: COSMOSIL, Polaris,

L8

单分子层丙氨基化学键合于10u硅胶载体,

NH2: COSMOSIL, Polaris,

L9

强酸性阳离子交换基团键合于10u无定形多孔硅胶,

SCX:Nucleosil SA; HYPERSIL

L10

氰基化学键合于5-10u多孔硅胶颗粒,

CN:COSMOSIL, Polaris

L11

苯基化学键合于5-10u多孔硅胶颗粒,

苯基柱:COSMOSIL,KROMASIL

L12

季铵基化学键合于30-50u固体硅胶小球上,强阴离子交换填料

 

L13

三甲基硅烷化学键合于5-10u多孔硅胶颗粒,

C1(TMS):COSMOSIL, KROMASIL

L14

带强碱性季铵基的阴离子交换涂料化学键合于10u硅胶微粒,

SAX: Nucleosil SB;Hypersil;Zorbax

L15

六烷基化学键合于全多孔硅胶颗粒,3-10u

C6:Allsphere,Chromegabond

L16

二甲基化学键合于全多孔硅胶颗粒,5-10u

C2:Nucleosil,Adsorbosil

L17

强阳离子交换树脂:氢型、磺化交联的苯乙烯二乙烯基苯共聚物,7-11u

Hamilton HC 75氢型柱, PL- Hi-Plex H

L18

氨基和氰基官能团键合于5-10u的多孔硅胶颗粒上

Partsil PAC

L19

强阳离子交换树脂:钙型、磺化交联的苯乙烯二乙烯基苯共聚物,9u

Hamilton HC 75钙型柱,PL- Hi-Plex Ca

L20

二羟基丙烷基团化学键合于多孔硅胶颗粒,5-10u

Diol:Nucleosil

L21

刚性的苯乙烯二乙烯基苯共聚物小球,5-10u

PRP-1:Hamilton;PLRP-S

L22

阳离子交换树脂:带磺酸基团的多孔苯乙烯聚合物小球,外径约10u

Hamilton PRP-X200,   

L23

阴离子交换树脂:带季铵基团的聚甲基丙烯酸甲酯或聚丙烯酸甲酯多孔胶体,约10u外径

TSK-DEAE-5PW, COSMOGEL QA

L24

基体表面带大量羟基团的聚乙烯构成的半刚性亲水凝胶,32-63u外径

 

L25

该填料应能分离分子量从100-5000道尔顿的化合物,用于分离中性,阳离子型及阴离子型的水溶性聚合物。以聚甲基丙烯酸甲酯树脂为载体,交联聚甲氧基乙醚,表面含有残留羰基基团

GFC:Macrosphere(7u),

Shodex Ohpak SB-802.5

L26

丁基硅烷化学键合于全多孔硅胶颗粒上,5-10u

C4:COSMOSIL, KROMASIL

L27

多孔硅胶颗粒,30-50u外径

 

L28

100埃的高纯、球形硅胶键合以阴离子性以及C8基团的多功能载体

 液色迷人http://hplc2.blog.163.com

L29

γ氧化铝,反相,含碳率低,氧化铝基的聚丁二烯小球,5u,80埃

GammaBond RP1

L30

乙基硅烷化学键合于多孔硅胶上,3-10u外径

C2:Nucleosil,Adsorbosil

L31

强阴离子交换树脂:季铵基键合于乳胶颗粒上,分散于8.5u大小,孔径2000埃的乙基乙烯基苯和二乙烯基苯(55%)的交连聚合物颗粒中

液色迷人http://hplc2.blog.163.com

L32

配位体交换手性填料:L—脯氨酸铜共价键合于不规则硅胶颗粒上,5-10u

COSMOSIL CSP-HPR,Nucleosil chiral-1

L33

能够分离4000-400,000道尔顿的蛋白质,球形硅胶载体,具PH稳定性

Nucleosil 125-5 GFC,TSK G3000SW

L34

强阳离子交换树脂:铅型、磺化交联的苯乙烯二乙烯基苯共聚物,9u

Hamilton HC 75铅型柱,Hi-Plex Pb

L35

经锆强化的球形硅胶颗粒,亲水性单分子层键合,孔径150埃

Zorbax GF-250

L36

L—苯基甘氨酸的3,5—二硝基苯甲酰衍生物共价键合在 5um的氨丙基硅胶上

Nucleosil chiral-3 手性柱

L37

能分离2,000—40,000分子量蛋白质的聚甲基丙烯酸凝胶

Shodex  OHpak SB-803HQ

L38

分离水溶性样品的甲基丙烯酸机质的体积排阻填料

Shodex  OHpak SB-802HQ

L39

亲水性 聚羟甲基丙烯酸 全多孔球形树脂

Shodex  OHpak SB-800系列

L40

3,5二甲苯甲氨酸纤维素涂布在5到20um的多孔硅胶上

CHIRALCEL OD; NUCLEOCEL DELTA

L41

固化ALPHA酸糖蛋白在5um的硅胶颗粒上

Chiral-AGP,

L42

C8和C18烷基化学键合于多孔硅胶微粒,5u

 

L43

五氟苯基化学键合在5-10u的硅胶微粒上

TAXSIL五氟苯基柱:常做紫杉醇分析用

L44

A multifunctional support,which consists of a high purity, 60?, spherical silica substrate that has been bonded with a cationic exchanger,sulphonic acid functionality in addition to a conventional reversed-phase C8 functionality.

Chromegabond RP-SCX

L45

Beta cyclodextrin bonded to porous silica particles, 5 to 10um in diameter

NUCLEODEX β-OH; ChirDex

L47

High capacity anion exchagne microporous substrate,8um in diameter,dimension 250 x 4.0mm

Dionex CarboPac MA1

L49

A reverse-phase packing made by coating a thin layer of polybutadiene on to a spherical porous zirconia particles, 3 to 10um

PBD柱

L50

A strong cation exchange resin made of porous silica with sulphopropyl groups, 5 to 10um in diameter.

TSK IC SW

L51

Amylose tris-3,5-dimethylphenylcarbamate-coated,porous,spherical,silica particles,5 to 10um in diameter

Chiralpak AD; NUCLEOCEL ALPHA

L52

A strong cation-exchange resin made of porous silica with sulphopropyl groups,5 to 10um in diameter.

TSKgel IC-Cation , TSKgel SP-2SW

L53

Weak cation-exchange resin consisting of ethylvinylbenzene,55% cross-linked with divinylbenzene polymer,3 to 15um in diameter.Substrate is surface grafted with carboxylic acid and/or phosphoric acid functionalized monomers.Capacity not less than 500uEq/column.

IonPac CS14

L54

A size exclusion medium made of covalent bonding of dextran to highly cross-linked porous agarose beads, about 13um in diameter.

Superdex Peptide HR 10/30

L55

A strong cation-exchange resin made of poroous silica coated with polybutadiene-maleic acid copolymer,about 5um in diameter.

 

L56

Propyl silane chemically bonded to totally porous silica particles,3 to 10um in diameter

Zorbax SB-C3

L57

Chiral recognition protein, ucoid, chemically bonded to silica , about 5um, with a pore size of 120A

ES-OVM手性柱

L58

Strong cation-exchange resin consisting of sulphonated cross-linked styrene-divinylbenzene copolymer in the sodium form, about 7 to 11um diameter

PL Hi-Plex Na

L59

Packing having the capacity to separate proteins by molecular weight over the range of 10 to 500kDa. It is spherical(10um), silica-based,and processed to provide hydrophilic characteristics and pH stability

TSKgel G3000SW

L60

Spherical porous silica gel,3 or 5um in diameter, the surface of which has been covalently modified with palmitamidopropyl groups and endcapped.

NUCLEOSIL? C18 Nautilus

L61

A hydroxide-selective,strong anion-exchange resin consisting of a highly cross-linked core of 13um microporous particles having a pore size less than 10 angstrom and consisting of ethylvinylbenzene cross-linked with 55% divinylbenzene with a latex coating composed of 85nm diameter microbeads bonded with alkanol quaternary ammonium ions(6%)

IonPac AS-11

L62

C30 silane bonded phase on a fully proous spherical silica,3 to 15um in diameter

Develosil C 30, YMC C30

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